Modulation of TRP channels by N-glycosylation and phosphorylation

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Transient receptor potential (TRP) are cation permeable channels found in eukaryotic organisms, from yeast to human. These channels are involved in several physiological processes ranging from Ca2+ and Mg2+ homeostasis to sensory functions, including vision, pheromone signalling, taste, nociception, mechanotransduction and temperature sensing, among others. Most of these channels show covalent post-translational modifications (PTMs) that have a profound effect on their physiological function, by influencing their subcellular trafficking and/or their biophysical properties. Among these modifications, N-linked glycosylation and phosphorylation are two of the most relevant PTMs determining the functional expression of TRP channels. In this chapter we summarize their role in modulating the functional properties of TRP channels, with a critical role in sensory transduction.

LanguageEnglish
Title of host publicationTRP Channels in Sensory Transduction
PublisherSpringer International Publishing
Pages73-96
Number of pages24
ISBN (Print)9783319187051, 9783319187044
DOIs
StatePublished - 24 Aug 2015

Fingerprint

Transient Receptor Potential Channels
post-translational modification
glycosylation
Glycosylation
phosphorylation
Phosphorylation
Post Translational Protein Processing
nociception
pheromones
Physiological Phenomena
functional properties
homeostasis
cations
Nociception
Pheromones
yeasts
receptors
organisms
Homeostasis
Yeasts

Keywords

  • N-glycosylation
  • Phosphorylation
  • Post-translational modifications
  • TRP channels

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)
  • Agricultural and Biological Sciences(all)

Cite this

Pertusa, M., & Madrid, R. (2015). Modulation of TRP channels by N-glycosylation and phosphorylation. In TRP Channels in Sensory Transduction (pp. 73-96). Springer International Publishing. DOI: 10.1007/978-3-319-18705-1_3

Modulation of TRP channels by N-glycosylation and phosphorylation. / Pertusa, María; Madrid, Rodolfo.

TRP Channels in Sensory Transduction. Springer International Publishing, 2015. p. 73-96.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pertusa, M & Madrid, R 2015, Modulation of TRP channels by N-glycosylation and phosphorylation. in TRP Channels in Sensory Transduction. Springer International Publishing, pp. 73-96. DOI: 10.1007/978-3-319-18705-1_3
Pertusa M, Madrid R. Modulation of TRP channels by N-glycosylation and phosphorylation. In TRP Channels in Sensory Transduction. Springer International Publishing. 2015. p. 73-96. Available from, DOI: 10.1007/978-3-319-18705-1_3
Pertusa, María ; Madrid, Rodolfo. / Modulation of TRP channels by N-glycosylation and phosphorylation. TRP Channels in Sensory Transduction. Springer International Publishing, 2015. pp. 73-96
@inbook{ef8ad1daf65549ecb81a420d3a695b78,
title = "Modulation of TRP channels by N-glycosylation and phosphorylation",
abstract = "Transient receptor potential (TRP) are cation permeable channels found in eukaryotic organisms, from yeast to human. These channels are involved in several physiological processes ranging from Ca2+ and Mg2+ homeostasis to sensory functions, including vision, pheromone signalling, taste, nociception, mechanotransduction and temperature sensing, among others. Most of these channels show covalent post-translational modifications (PTMs) that have a profound effect on their physiological function, by influencing their subcellular trafficking and/or their biophysical properties. Among these modifications, N-linked glycosylation and phosphorylation are two of the most relevant PTMs determining the functional expression of TRP channels. In this chapter we summarize their role in modulating the functional properties of TRP channels, with a critical role in sensory transduction.",
keywords = "N-glycosylation, Phosphorylation, Post-translational modifications, TRP channels",
author = "Mar{\'i}a Pertusa and Rodolfo Madrid",
year = "2015",
month = "8",
day = "24",
doi = "10.1007/978-3-319-18705-1_3",
language = "English",
isbn = "9783319187051",
pages = "73--96",
booktitle = "TRP Channels in Sensory Transduction",
publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Modulation of TRP channels by N-glycosylation and phosphorylation

AU - Pertusa,María

AU - Madrid,Rodolfo

PY - 2015/8/24

Y1 - 2015/8/24

N2 - Transient receptor potential (TRP) are cation permeable channels found in eukaryotic organisms, from yeast to human. These channels are involved in several physiological processes ranging from Ca2+ and Mg2+ homeostasis to sensory functions, including vision, pheromone signalling, taste, nociception, mechanotransduction and temperature sensing, among others. Most of these channels show covalent post-translational modifications (PTMs) that have a profound effect on their physiological function, by influencing their subcellular trafficking and/or their biophysical properties. Among these modifications, N-linked glycosylation and phosphorylation are two of the most relevant PTMs determining the functional expression of TRP channels. In this chapter we summarize their role in modulating the functional properties of TRP channels, with a critical role in sensory transduction.

AB - Transient receptor potential (TRP) are cation permeable channels found in eukaryotic organisms, from yeast to human. These channels are involved in several physiological processes ranging from Ca2+ and Mg2+ homeostasis to sensory functions, including vision, pheromone signalling, taste, nociception, mechanotransduction and temperature sensing, among others. Most of these channels show covalent post-translational modifications (PTMs) that have a profound effect on their physiological function, by influencing their subcellular trafficking and/or their biophysical properties. Among these modifications, N-linked glycosylation and phosphorylation are two of the most relevant PTMs determining the functional expression of TRP channels. In this chapter we summarize their role in modulating the functional properties of TRP channels, with a critical role in sensory transduction.

KW - N-glycosylation

KW - Phosphorylation

KW - Post-translational modifications

KW - TRP channels

UR - http://www.scopus.com/inward/record.url?scp=84955380186&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955380186&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-18705-1_3

DO - 10.1007/978-3-319-18705-1_3

M3 - Chapter

SN - 9783319187051

SN - 9783319187044

SP - 73

EP - 96

BT - TRP Channels in Sensory Transduction

PB - Springer International Publishing

ER -