Can physical activity attenuate the negative association between sitting time and cognitive function among older adults? A mediation analysis

A. García-Hermoso, R. Ramírez-Vélez, C.A. Celis-Morales, J. Olloquequi, M. Izquierdo

Research output: Contribution to journalArticle

  • 1 Citations

Abstract

The purpose of this study was to examine the combined association of sitting time and physical activity with cognitive function and to determine whether moderate-to-vigorous physical activity (MVPA) is a mediator of the association between sitting time and cognitive function in a nationally representative sample of older adults from Chile. Data from 989 older adults (≥65 years old, 61.3% female) from the 2009–2010 Chilean Health Survey were analyzed. Physical activity and sitting time were measured using the Global Physical Activity questionnaire. Cognitive function was assessed using the modified Mini-Mental State levels Examination. Physical activity levels were categorized as “inactive” (
LanguageEnglish
Pages173-177
Number of pages5
JournalExperimental Gerontology
Volume106
DOIs
Publication statusPublished - 2018

Fingerprint

Cognition
Chile
Health Surveys
Surveys and Questionnaires

Keywords

  • Aging
  • Cognitive impairment
  • Physical inactivity
  • Sedentary behavior
  • aged
  • alcohol consumption
  • Article
  • attention
  • body mass
  • cognitive defect
  • Composite International Diagnostic Interview
  • controlled study
  • depression
  • depression assessment
  • disease association
  • DSM-IV
  • female
  • human
  • language
  • major clinical study
  • male
  • memory
  • metabolic equivalent
  • Mini Mental State Examination
  • orientation
  • physical activity
  • prevalence
  • priority journal
  • sitting
  • tobacco use

Cite this

Can physical activity attenuate the negative association between sitting time and cognitive function among older adults? A mediation analysis. / García-Hermoso, A.; Ramírez-Vélez, R.; Celis-Morales, C.A.; Olloquequi, J.; Izquierdo, M.

In: Experimental Gerontology, Vol. 106, 2018, p. 173-177.

Research output: Contribution to journalArticle

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abstract = "The purpose of this study was to examine the combined association of sitting time and physical activity with cognitive function and to determine whether moderate-to-vigorous physical activity (MVPA) is a mediator of the association between sitting time and cognitive function in a nationally representative sample of older adults from Chile. Data from 989 older adults (≥65 years old, 61.3{\%} female) from the 2009–2010 Chilean Health Survey were analyzed. Physical activity and sitting time were measured using the Global Physical Activity questionnaire. Cognitive function was assessed using the modified Mini-Mental State levels Examination. Physical activity levels were categorized as “inactive” (",
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author = "A. Garc{\'i}a-Hermoso and R. Ram{\'i}rez-V{\'e}lez and C.A. Celis-Morales and J. Olloquequi and M. Izquierdo",
note = "Export Date: 23 May 2018 CODEN: EXGEA Correspondence Address: Izquierdo, M.; Department of Health Sciences, Public University of Navarra (Navarra), Campus of Tudela, Av. de Tarazona s/n., Spain; email: mikel.izquierdo@gmail.com References: Aguilar-Farias, N., Leppe Zamora, J., Is a single question of the Global Physical Activity Questionnaire (GPAQ) valid for measuring sedentary behaviour in the Chilean population? (2017) J. Sports Sci., 35 (16), pp. 1652-1657; Aguilar-Farias, N., Martino-Fuentealba, P., Cort{\'i}nez-O'Ryan, A., The descriptive epidemiology of sitting in Chilean adults: results from the National Health Survey 2009-2010 (2017) J. Sport Health Sci.; Alvarado, M.E., Garmendia, M.L., Acu{\~n}a, G., Assessment of the alcohol use disorders identification test (AUDIT) to detect problem drinkers (2009) Rev. Med. Chil., 137 (11), pp. 1463-1468; Armstrong, T., Bull, F., Development of the world health organization global physical activity questionnaire (GPAQ) (2006) J. Pub. Health, 14 (2), pp. 66-70; Asztalos, M., Cardon, G., De Bourdeaudhuij, I., Cross-sectional associations between sitting time and several aspects of mental health in Belgian adults (2015) J. Phys. Act. Health, 12 (8), pp. 1112-1118; Barnes, J., Behrens, T.K., Benden, M.E., Letter to the editor: standardized use of the terms “sedentary” and “sedentary behaviours” (2012) Appl. Physiol. Nutr. Metab., 37 (3), pp. 540-542; Bellou, V., Belbasis, L., Tzoulaki, I., Systematic evaluation of the associations between environmental risk factors and dementia: an umbrella review of systematic reviews and meta-analyses (2017) Alzheimers Dement., 13 (4), pp. 406-418; Biswas, A., Oh, P.I., Faulkner, G.E., Sedentary time and its association with risk for disease incidence, mortality, and hospitalization in adults: a systematic review and meta-analysis sedentary time and disease incidence, mortality, and hospitalization (2015) Ann. Intern. Med., 162 (2), pp. 123-132; Casas-Herrero, A., Cadore, E.L., Zambom-Ferraresi, F., Functional capacity, muscle fat infiltration, power output, and cognitive impairment in institutionalized frail oldest old (2013) Rejuvenation Res., 16 (5), pp. 396-403; Celis-Morales, C., Salas, C., Alduhishy, A., Socio-demographic patterns of physical activity and sedentary behaviour in Chile: results from the National Health Survey 2009–2010 (2016) J. Public Health, 38 (2); Deary, I.J., Corley, J., Gow, A.J., Age-associated cognitive decline (2009) Br. Med. Bull., 92 (1), pp. 135-152; Dogra, S., Stathokostas, L., Sedentary behavior and physical activity are independent predictors of successful aging in middle-aged and older adults (2012) J. Aging Res., 2012; Dogra, S., Ashe, M.C., Biddle, S.J., Sedentary time in older men and women: an international consensus statement and research priorities (2017) Br. J. Sports Med., 51 (21), pp. 1526-1532. , bjsports-2016-097209; Edwards, M.K., Loprinzi, P.D., The fat-but-fit paradigm within the context of cognitive function (2017) Am. J. Hum. Biol., 29 (5); Edwards, M.K., Loprinzi, P.D., The association between sedentary behavior and cognitive function among older adults may be attenuated with adequate physical activity (2017) J. Phys. Act. Health, 14 (1), pp. 52-58; Ekelund, U., Steene-Johannessen, J., Brown, W.J., Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women (2016) Lancet, 388 (10051), pp. 1302-1310; (2010), http://web.minsal.cl/portal/url/item/bcb03d7bc28b64dfe040010165012d23.pdf, [on-line]. Available at Accessed 10 January, 2017; Falck, R.S., Davis, J.C., Liu-Ambrose, T., What is the association between sedentary behaviour and cognitive function? A systematic review (2017) Br. J. Sports Med., 51 (10), pp. 800-811; Folstein, M.F., Folstein, S.E., McHugh, P.R., “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician (1975) J. Psychiatr. Res., 12 (3), pp. 189-198; Friedman, E.M., Shih, R.A., Slaughter, M.E., Neighborhood age structure and cognitive function in a nationally-representative sample of older adults in the US (2017) Soc. Sci. Med., 174, pp. 149-158; Garc{\'i}a-Hermoso, A., Mart{\'i}nez-Vizca{\'i}no, V., S{\'a}nchez-L{\'o}pez, M., Moderate-to-vigorous physical activity as a mediator between sedentary behavior and cardiometabolic risk in Spanish healthy adults: a mediation analysis (2015) Int. J. Behav. Nutr. Phys. Act., 12 (1), p. 78; Garc{\'i}a-Hermoso, A., Ram{\'i}rez-V{\'e}lez, R., Ramirez-Campillo, R., Prevalence of ideal cardiovascular health and its association with cognitive function in older adults: the Chilean National Health Survey (2009–2010) (2017) Rejuvenation Res.; Gow, A.J., Bastin, M.E., Maniega, S.M., Neuroprotective lifestyles and the aging brain activity, atrophy, and white matter integrity (2012) Neurology, 79 (17), pp. 1802-1808; Hallal, P.C., Andersen, L.B., Bull, F.C., Global physical activity levels: surveillance progress, pitfalls, and prospects (2012) Lancet, 380 (9838), pp. 247-257; Jacova, C., Kertesz, A., Blair, M., Neuropsychological testing and assessment for dementia (2007) Alzheimers Dement., 3 (4), pp. 299-317; Katzmarzyk, P.T., Church, T.S., Craig, C.L., Sitting time and mortality from all causes, cardiovascular disease, and cancer (2009) Med. Sci. Sports Exerc., 41 (5), pp. 998-1005; Kessler, R.C., Andrews, G., Mroczek, D., The World Health Organization composite international diagnostic interview short-form (CIDI-SF) (1998) Int. J. Methods Psychiatr. Res., 7 (4), pp. 171-185; Ku, P.-W., Liu, Y.-T., Lo, M.-K., Higher levels of objectively measured sedentary behavior is associated with worse cognitive ability: two-year follow-up study in community-dwelling older adults (2017) Exp. Gerontol., 99, pp. 110-114; Loprinzi, P.D., Crush, E., Joyner, C., Cardiovascular disease biomarkers on cognitive function in older adults: joint effects of cardiovascular disease biomarkers and cognitive function on mortality risk (2017) Prev. Med., 94, pp. 27-30; Marques, A., Peralta, M., Martins, J., Cross-sectional and prospective relationship between physical activity and chronic diseases in European older adults (2017) Int. J. Public Health, 62 (4), pp. 495-502; Owen, N., Healy, G.N., Matthews, C.E., Too much sitting: the population-health science of sedentary behavior (2010) Exerc. Sport Sci. Rev., 38 (3), p. 105; Preacher, K.J., Hayes, A.F., Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models (2008) Behav. Res. Methods, 40 (3), pp. 879-891; Quiroga, P., Albala Brevis, C., Klaasen, G., Validation of a Screening Test for Age Associated Cognitive Impairment, in Chile (2004); Riebe, D., Blissmer, B.J., Greaney, M.L., The relationship between obesity, physical activity, and physical function in older adults (2009) J. Aging Health, 21 (8), pp. 1159-1178; Salthouse, T., Consequences of age-related cognitive declines (2012) Annu. Rev. Psychol., 63, pp. 201-226; Steinberg, S.I., Sammel, M.D., Harel, B.T., Exercise, sedentary pastimes, and cognitive performance in healthy older adults (2015) Am. J. Alzheimers Dis. Other Demen., 30 (3), pp. 290-298; Stranahan, M., Martin, B., Maudsley, S., Anti-inflammatory effects of physical activity in relationship to improved cognitive status in humans and mouse models of Alzheimer's disease (2012) Curr. Alzheimer Res., 9 (1), pp. 86-92; Ten Brinke, L.F., Bolandzadeh, N., Nagamatsu, L.S., Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial (2015) Br. J. Sports Med., 49 (4), pp. 248-254. , bjsports-2013-093184; Wimo, A., Prince, M., World Alzheimer Report 2010: The Global Economic Impact of Dementia (2010), Alzheimer's Disease International London, UK; Zhu, W., Wadley, V.G., Howard, V.J., Objectively measured physical activity and cognitive function in older adults (2017) Med. Sci. Sports Exerc., 49 (1), pp. 47-53",
year = "2018",
doi = "10.1016/j.exger.2018.03.002",
language = "English",
volume = "106",
pages = "173--177",
journal = "Experimental Gerontology",
issn = "0531-5565",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Can physical activity attenuate the negative association between sitting time and cognitive function among older adults? A mediation analysis

AU - García-Hermoso, A.

AU - Ramírez-Vélez, R.

AU - Celis-Morales, C.A.

AU - Olloquequi, J.

AU - Izquierdo, M.

N1 - Export Date: 23 May 2018 CODEN: EXGEA Correspondence Address: Izquierdo, M.; Department of Health Sciences, Public University of Navarra (Navarra), Campus of Tudela, Av. de Tarazona s/n., Spain; email: mikel.izquierdo@gmail.com References: Aguilar-Farias, N., Leppe Zamora, J., Is a single question of the Global Physical Activity Questionnaire (GPAQ) valid for measuring sedentary behaviour in the Chilean population? (2017) J. Sports Sci., 35 (16), pp. 1652-1657; Aguilar-Farias, N., Martino-Fuentealba, P., Cortínez-O'Ryan, A., The descriptive epidemiology of sitting in Chilean adults: results from the National Health Survey 2009-2010 (2017) J. Sport Health Sci.; Alvarado, M.E., Garmendia, M.L., Acuña, G., Assessment of the alcohol use disorders identification test (AUDIT) to detect problem drinkers (2009) Rev. Med. Chil., 137 (11), pp. 1463-1468; Armstrong, T., Bull, F., Development of the world health organization global physical activity questionnaire (GPAQ) (2006) J. Pub. Health, 14 (2), pp. 66-70; Asztalos, M., Cardon, G., De Bourdeaudhuij, I., Cross-sectional associations between sitting time and several aspects of mental health in Belgian adults (2015) J. Phys. Act. Health, 12 (8), pp. 1112-1118; Barnes, J., Behrens, T.K., Benden, M.E., Letter to the editor: standardized use of the terms “sedentary” and “sedentary behaviours” (2012) Appl. Physiol. Nutr. Metab., 37 (3), pp. 540-542; Bellou, V., Belbasis, L., Tzoulaki, I., Systematic evaluation of the associations between environmental risk factors and dementia: an umbrella review of systematic reviews and meta-analyses (2017) Alzheimers Dement., 13 (4), pp. 406-418; Biswas, A., Oh, P.I., Faulkner, G.E., Sedentary time and its association with risk for disease incidence, mortality, and hospitalization in adults: a systematic review and meta-analysis sedentary time and disease incidence, mortality, and hospitalization (2015) Ann. Intern. Med., 162 (2), pp. 123-132; Casas-Herrero, A., Cadore, E.L., Zambom-Ferraresi, F., Functional capacity, muscle fat infiltration, power output, and cognitive impairment in institutionalized frail oldest old (2013) Rejuvenation Res., 16 (5), pp. 396-403; Celis-Morales, C., Salas, C., Alduhishy, A., Socio-demographic patterns of physical activity and sedentary behaviour in Chile: results from the National Health Survey 2009–2010 (2016) J. Public Health, 38 (2); Deary, I.J., Corley, J., Gow, A.J., Age-associated cognitive decline (2009) Br. Med. Bull., 92 (1), pp. 135-152; Dogra, S., Stathokostas, L., Sedentary behavior and physical activity are independent predictors of successful aging in middle-aged and older adults (2012) J. Aging Res., 2012; Dogra, S., Ashe, M.C., Biddle, S.J., Sedentary time in older men and women: an international consensus statement and research priorities (2017) Br. J. Sports Med., 51 (21), pp. 1526-1532. , bjsports-2016-097209; Edwards, M.K., Loprinzi, P.D., The fat-but-fit paradigm within the context of cognitive function (2017) Am. J. Hum. Biol., 29 (5); Edwards, M.K., Loprinzi, P.D., The association between sedentary behavior and cognitive function among older adults may be attenuated with adequate physical activity (2017) J. Phys. Act. Health, 14 (1), pp. 52-58; Ekelund, U., Steene-Johannessen, J., Brown, W.J., Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women (2016) Lancet, 388 (10051), pp. 1302-1310; (2010), http://web.minsal.cl/portal/url/item/bcb03d7bc28b64dfe040010165012d23.pdf, [on-line]. Available at Accessed 10 January, 2017; Falck, R.S., Davis, J.C., Liu-Ambrose, T., What is the association between sedentary behaviour and cognitive function? A systematic review (2017) Br. J. Sports Med., 51 (10), pp. 800-811; Folstein, M.F., Folstein, S.E., McHugh, P.R., “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician (1975) J. Psychiatr. Res., 12 (3), pp. 189-198; Friedman, E.M., Shih, R.A., Slaughter, M.E., Neighborhood age structure and cognitive function in a nationally-representative sample of older adults in the US (2017) Soc. Sci. Med., 174, pp. 149-158; García-Hermoso, A., Martínez-Vizcaíno, V., Sánchez-López, M., Moderate-to-vigorous physical activity as a mediator between sedentary behavior and cardiometabolic risk in Spanish healthy adults: a mediation analysis (2015) Int. J. Behav. Nutr. Phys. Act., 12 (1), p. 78; García-Hermoso, A., Ramírez-Vélez, R., Ramirez-Campillo, R., Prevalence of ideal cardiovascular health and its association with cognitive function in older adults: the Chilean National Health Survey (2009–2010) (2017) Rejuvenation Res.; Gow, A.J., Bastin, M.E., Maniega, S.M., Neuroprotective lifestyles and the aging brain activity, atrophy, and white matter integrity (2012) Neurology, 79 (17), pp. 1802-1808; Hallal, P.C., Andersen, L.B., Bull, F.C., Global physical activity levels: surveillance progress, pitfalls, and prospects (2012) Lancet, 380 (9838), pp. 247-257; Jacova, C., Kertesz, A., Blair, M., Neuropsychological testing and assessment for dementia (2007) Alzheimers Dement., 3 (4), pp. 299-317; Katzmarzyk, P.T., Church, T.S., Craig, C.L., Sitting time and mortality from all causes, cardiovascular disease, and cancer (2009) Med. Sci. Sports Exerc., 41 (5), pp. 998-1005; Kessler, R.C., Andrews, G., Mroczek, D., The World Health Organization composite international diagnostic interview short-form (CIDI-SF) (1998) Int. J. Methods Psychiatr. Res., 7 (4), pp. 171-185; Ku, P.-W., Liu, Y.-T., Lo, M.-K., Higher levels of objectively measured sedentary behavior is associated with worse cognitive ability: two-year follow-up study in community-dwelling older adults (2017) Exp. Gerontol., 99, pp. 110-114; Loprinzi, P.D., Crush, E., Joyner, C., Cardiovascular disease biomarkers on cognitive function in older adults: joint effects of cardiovascular disease biomarkers and cognitive function on mortality risk (2017) Prev. Med., 94, pp. 27-30; Marques, A., Peralta, M., Martins, J., Cross-sectional and prospective relationship between physical activity and chronic diseases in European older adults (2017) Int. J. Public Health, 62 (4), pp. 495-502; Owen, N., Healy, G.N., Matthews, C.E., Too much sitting: the population-health science of sedentary behavior (2010) Exerc. Sport Sci. Rev., 38 (3), p. 105; Preacher, K.J., Hayes, A.F., Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models (2008) Behav. Res. Methods, 40 (3), pp. 879-891; Quiroga, P., Albala Brevis, C., Klaasen, G., Validation of a Screening Test for Age Associated Cognitive Impairment, in Chile (2004); Riebe, D., Blissmer, B.J., Greaney, M.L., The relationship between obesity, physical activity, and physical function in older adults (2009) J. Aging Health, 21 (8), pp. 1159-1178; Salthouse, T., Consequences of age-related cognitive declines (2012) Annu. Rev. Psychol., 63, pp. 201-226; Steinberg, S.I., Sammel, M.D., Harel, B.T., Exercise, sedentary pastimes, and cognitive performance in healthy older adults (2015) Am. J. Alzheimers Dis. Other Demen., 30 (3), pp. 290-298; Stranahan, M., Martin, B., Maudsley, S., Anti-inflammatory effects of physical activity in relationship to improved cognitive status in humans and mouse models of Alzheimer's disease (2012) Curr. Alzheimer Res., 9 (1), pp. 86-92; Ten Brinke, L.F., Bolandzadeh, N., Nagamatsu, L.S., Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial (2015) Br. J. Sports Med., 49 (4), pp. 248-254. , bjsports-2013-093184; Wimo, A., Prince, M., World Alzheimer Report 2010: The Global Economic Impact of Dementia (2010), Alzheimer's Disease International London, UK; Zhu, W., Wadley, V.G., Howard, V.J., Objectively measured physical activity and cognitive function in older adults (2017) Med. Sci. Sports Exerc., 49 (1), pp. 47-53

PY - 2018

Y1 - 2018

N2 - The purpose of this study was to examine the combined association of sitting time and physical activity with cognitive function and to determine whether moderate-to-vigorous physical activity (MVPA) is a mediator of the association between sitting time and cognitive function in a nationally representative sample of older adults from Chile. Data from 989 older adults (≥65 years old, 61.3% female) from the 2009–2010 Chilean Health Survey were analyzed. Physical activity and sitting time were measured using the Global Physical Activity questionnaire. Cognitive function was assessed using the modified Mini-Mental State levels Examination. Physical activity levels were categorized as “inactive” (

AB - The purpose of this study was to examine the combined association of sitting time and physical activity with cognitive function and to determine whether moderate-to-vigorous physical activity (MVPA) is a mediator of the association between sitting time and cognitive function in a nationally representative sample of older adults from Chile. Data from 989 older adults (≥65 years old, 61.3% female) from the 2009–2010 Chilean Health Survey were analyzed. Physical activity and sitting time were measured using the Global Physical Activity questionnaire. Cognitive function was assessed using the modified Mini-Mental State levels Examination. Physical activity levels were categorized as “inactive” (

KW - Aging

KW - Cognitive impairment

KW - Physical inactivity

KW - Sedentary behavior

KW - aged

KW - alcohol consumption

KW - Article

KW - attention

KW - body mass

KW - cognitive defect

KW - Composite International Diagnostic Interview

KW - controlled study

KW - depression

KW - depression assessment

KW - disease association

KW - DSM-IV

KW - female

KW - human

KW - language

KW - major clinical study

KW - male

KW - memory

KW - metabolic equivalent

KW - Mini Mental State Examination

KW - orientation

KW - physical activity

KW - prevalence

KW - priority journal

KW - sitting

KW - tobacco use

U2 - 10.1016/j.exger.2018.03.002

DO - 10.1016/j.exger.2018.03.002

M3 - Article

VL - 106

SP - 173

EP - 177

JO - Experimental Gerontology

T2 - Experimental Gerontology

JF - Experimental Gerontology

SN - 0531-5565

ER -